If you’re just starting out, the trickiest part is learning how each potion corresponds to its effect. Since the game doesn’t offer hints or a built-in reference, it helps to have a quick chart handy and The Apothecary of Trubiz Guide.
Here’s a simple list of every potion based on their position in your brewing grid (left to right, top to bottom):
- Turquoise
- Red
- Blue
- Purple
- Green
- Lilas
- Deep Blue
- Cyan
- Orange
- Black
Second-row special variations:
11. Shaked Orange
12. Shaked Green
13. Rainbow
14. Red-Black
Once you get familiar with these, diagnosing patients becomes much smoother.
POTION ACHIEVEMENTS
First Potion
Brew any potion. Straightforward and impossible to miss.
Thermal Reaction
Heat or cool a potion until it changes state.
Stirring Technique
Shake a potion to alter it.
Temporal Reaction
Leave a potion untouched long enough for time to transform it naturally.
ENDINGS
Ending #1 – The Apothecary of Trubiz
You must cure every patient fully, including their hidden illnesses. The list below gives you every correct combination for each day.
Day 1
- Cough: Turquoise
- Fever: Red
Day 2
- Headache & Dizziness: Purple + Rainbow
- Nausea: Lilas
- Heaviness & Insomnia: Blue + Deep Blue
Day 3
- Depression: Black
- Heaviness & Stomach Ache: Blue + Cyan
- Stress: Orange
Day 4
- Stomach Ache & Fever: Green + Red
- Stomach Ache & Nausea: Cyan + Lilas
Day 5
- Stomach Ache, Dizziness & Heaviness: Cyan + Rainbow + Blue
- Stomach Ache, Fever & Stress: Green + Red + Orange
- Stomach Ache & Insomnia: Deep Blue + Cyan
Day 6
- Insomnia & Depression: Shaked Green + Black
Day 7
- Insomnia, Cough & Stress: Deep Blue + Turquoise + Orange
- Insomnia & Nausea: Deep Blue + Lilas
Day 8
- Insomnia, Cough & Nausea: Deep Blue + Turquoise + Lilas
- Insomnia, Cough & Depression: Shaked Orange + Turquoise + Black
- Insomnia, Nausea & Depression: Shaked Green + Lilas + Black
Day 9
- Cough & Fever: Turquoise + Red
- Headache & Dizziness: Purple + Rainbow
Day 10
- Fever & Stomach Ache: Green + Red
- Cough, Insomnia & Stress: Turquoise + Deep Blue + Orange
- Depression, Insomnia & Nausea: Black + Shaked Green + Lilas
Once all patients are cured completely, this ending triggers automatically.
Ending #2 – Apothecary
Cure more than half of the total patients, but not all.
Ending #4 – Demotion
Cure less than half of your patients.
Ending #5 – Vacationing Apothecary
Treat no one for the entire run.
Ending #3 – The Legendary Quack
For this one, you must actively worsen every patient while also avoiding curing any symptom at all. You’ll need to give the wrong combinations intentionally.
Here’s the full breakdown of what makes their conditions worse:
Day 1
- Cough: Blue + Orange
- Fever: Turquoise + Shaked Green
Day 2
- Headache & Dizziness: Turquoise + Shaked Green
- Nausea: Turquoise + Shaked Green
- Heaviness & Insomnia: Red + Cyan
Day 3
- Depression: Turquoise + Shaked Green
- Heaviness & Stomach Ache: Turquoise + Shaked Green
- Stress: Turquoise + Shaked Green
Day 4
- Stomach Ache & Fever: Turquoise + Shaked Green
- Stomach Ache & Nausea: Turquoise + Shaked Green
Day 5
- Stomach Ache, Dizziness & Heaviness: Turquoise + Shaked Green
- Stomach Ache, Fever & Stress: Turquoise + Shaked Green
- Stomach Ache & Insomnia: Blue + Orange
Day 6
- Insomnia & Depression: Blue + Orange
Day 7
- Insomnia, Cough & Stress: Red + Cyan
- Insomnia & Nausea: Blue + Orange
Day 8
Same for all variations: Blue + Orange
Day 9
- Cough: Blue + Orange
- Headache: Turquoise + Shaked Green
Day 10
- Fever: Turquoise + Shaked Green
- Cough: Red + Cyan
- Depression: Blue + Orange
Complete all days this way to get the quack ending.
OTHER ACHIEVEMENTS
Treatment of Latent Illness
You earn this by solving a hidden illness, which naturally happens during Ending #1 (for example, Day 9).
Page Restoration
All manual pages must be found. A few appear sometime between Days 2–5.
Pages 19–20 hide behind the second library row—drag the bottom-right shelf left to reveal it.
All Endings
Experience every ending once.
Total Completion
Unlock all achievements.
That’s everything needed for a clean 100% run. Once you know the potion chart and understand how the illnesses combine, the game becomes far more straightforward.