Sephiria Talent Guide 2026 – Best Talent Setup

Talents are your permanent power foundation. While weapons and relics define your build direction, talents decide how smooth, safe, and explosive your runs actually feel. A well-built talent setup increases survivability, improves drop quality, accelerates scaling, and directly boosts late-game damage.

Talents also unlock two of the most powerful systems in the entire game: Tablet Imprinting and [Unique] Stacking, which completely change how strong your inventory becomes in long runs.

Because talent points are limited, choosing the right talents early saves hours of struggle later.

Best Overall Talent Priority (Recommended Order)

  1. Survival – Level 20

  2. Wisdom – Level 10

  3. Ingenuity – Level 20

  4. Swiftness – Level 20

  5. Wrath – Level 20

  6. Willpower – Level 10

  7. Endure – Level 10

  8. Willpower – Level 20

TALENTS

WRATH
Unleash your inner rage to deal massive damage to enemies.

+1% ~ +20% Critical Chance

Lv5
+20% Critical DMG

Lv10
+10% DMG against bosses/minibosses

Lv20
+20% Ignore DEF

SWIFTNESS
You act faster.

+1% ~ +20% ATK SPD

Lv5
+8 Evasion
+1 Dash

Lv10
+20% Dash Recovery SPD
+8% Weapon DMG

Lv20
+0.1s iframes during Dash
+15% Weapon DMG

SURVIVAL
Learn how to survive long adventures.

+2 ~ +40 Max HP

Lv5
+1 Random Stat when drinking any potion

Lv10
+3 Inventory Slots

Lv20
-12 Inventory Slots
Unlocks Tablet Imprinting

ENDURE
Learn how to tolerate pain.

+1 ~ +20 DEF

Lv5
Start with Foundation tablet

Lv10
Heal 1 HP/s when <25 HP

Lv20
On death, revive with 60% HP

WISDOM
Use MP more efficiently and increase your knowledge of artifacts.

+1 ~ +20 MP Regeneration

Lv5
+3 MP on Enemy Kill

Lv10
Unlocks [Unique] Stacking
+1 Dice on Boss Kill

Lv20
+1 Free Reroll per reward
+20% EXP Earned

WILLPOWER
Someone’s will grants you strength.

+1 ~ +20 Luck

Lv5
+2 Starting Dice
Increase Capacity of Wishing Fountain by 1

Lv10
+15 Max HP
+25 Max MP

Lv20
Increase Capacity of Wishing Fountain by 4

INGENUITY
Cleverly use item combos to create advantageous situations.

+1 ~ +20 Max HP
+0.5 ~ +10 Evasion

Lv5
+2 Inventory Slots

Lv10
+1 Extra Weapons, Items, and Miracles offered

Lv20
+7% All DMG for each active Combo Type

TABLET IMPRINTING

While in inventory, hold the imprint action to consume the tablet.
The boost from the consumed tablet will persist on the slot until the end of the run.

[UNIQUE] STACKING

Normally, items with [Unique] effects can only apply once, so they will no longer be offered as a reward when selecting.

[Unique] Stacking forces all items to be [Unique(Forced)].
[Unique] items will also be offered as a duplicate reward.
If taken, it will instead be used to +1★ the one in your inventory.
After it is at max ★, the item will no longer be offered.

WISHING FOUNTAIN

Can select Artifacts from the town to take into the next run.

Common = ▰▰▰
Advanced = ▰▰▰▰
Rare = ▰▰▰▰▰
Legendary = ▰▰▰▰▰▰

With the default capacity of 4, you may take:
1× Common ▰▰▰/▱▱
1× Advanced ▰▰▰▰/▱

With Lv5 capacity of 5, you may additionally take:
1× Rare ▰▰▰▰▰

With a maximum capacity of 9, you may take:

3× Common ▰▰▰/▰▰▰/▰▰▰
2× Advanced ▰▰▰▰/▰▰▰▰/▱
1× Rare + 1× Common ▰▰▰▰▰/▰▰▰/▱
1× Rare + 1× Advanced ▰▰▰▰▰/▰▰▰▰
1× Legendary + 1× Common ▰▰▰▰▰▰/▰▰▰